Bay Area Medical Information
Sleep Medicine Over-the-Counter
Diphenhydramine (Benadryl) is the most common ingredient in OTC sleep medicine

Tylenol PM has the following active ingredients:

  1. acetaminophen (Tylenol) and
  2. diphenhydramine (Benadryl) is a very effective antihistamine that relieves symptoms related to allergy. It is also a common ingredient in sleep aids because of its side effect of extreme drowsiness; however, this side effect does wear off with continuous use. Although diphenhydramine can be a satisfactory, intermittent sleep aid in a select group of healthy people, relying on it on a regular basis, will not work for 2 reasons: The drowsiness will wear off, and there is an increased risk of experiencing undesirable side effects, especially in the elderly. A common example is men with an enlarged prostate may experience urinary difficulty. Other Precautions: Asthma and lower respiratory disorders, glaucoma, hyperthyroidism, hypertension, cardiovascular disease, GI obstruction, urinary obstruction, children, pregnancy. Diphenhydramine interacts with: alcohol and other CNS depressants as well as MAOIs.

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